Hepatitis C Virus (hcv) Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice Expressing the Hcv Full- Length Open Reading Frame
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چکیده
HEPATITIS C VIRUS (HCV) PROTEINS INDUCE LIPOGENESIS AND DEFECTIVE TRIGLYCERIDE SECRETION IN TRANSGENIC MICE EXPRESSING THE HCV FULLLENGTH OPEN READING FRAME. Hervé Lerat, Hélène L. Kammoun, Isabelle Hainault, Emilie Mérour, Céline Callens, Stanley M Lemon, Fabienne Foufelle, and Jean-Michel Pawlotsky From INSERM U955, Créteil, France 1 ; INSERM U872, Université Paris 6, Paris, France 2 ; Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas 3 ; National Reference Center for Viral Hepatitis B, C and Delta, Department of Virology, Hôpital Henri Mondor, Université Paris 12, Créteil, France 4
منابع مشابه
Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice.
Chronic hepatitis C virus (HCV) infection is associated with altered lipid metabolism and hepatocellular steatosis. Virus-induced steatosis is a cytopathic effect of HCV replication. The goal of this study was to examine the mechanisms underlying HCV-induced lipid metabolic defects in a transgenic mouse model expressing the full HCV protein repertoire at levels corresponding to natural human in...
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